The Witcher

Rubedo is an additional, or secondary substance which is present in some alchemical ingredients in addition to the primary substance. All alchemical ingredients contain one of six basic substances: aether, hydragenum, quebrith, rebis, vermilion, and vitriol. There are also three additional substances: albedo, nigredo, and rubedo. Any given ingredient may contain only a single basic substance and potentially one additional, or secondary substance.
Rubedo potions: If all ingredients used to create a given potion contain rubedo as an additional substance, the resulting potion will increase the regeneration rate of vitality for 4 hours in addition to the potion's original effect.
The Witcher 3: Wild Hunt
Unlike previous games, Rubedo is not simply part of other alchemical ingredients. It is needed to craft the following items:
One dose is always dropped by Hubert Rejk if he is killed during Carnal Sins, but otherwise in the base game it must be crafted. In the Blood and Wine expansion, it can also be purchased from alchemists:
- Merchant at the Perfumery
- Wine Merchant at Chuchote Cave, after completing his quest
- Wine Merchant at Dun Tynne Hillside, after completing his quest
Trivia
- In alchemy, the rubedo means "coagulation" of the matter, and is the last step Magnum opus process.