E-I-E-I-OR was a loose parody of the TV medical drama ER on Muppets Tonight, featuring a hospital full of silly doctors and their animal patients delivering a fast-paced barrage of jokes. The sketches most prominently star Fozzie Bear and Dr. Payne.
The sketch can be seen as an updated version of the classic Veterinarian's Hospital skits from The Muppet Show.
Among the doctors are Afghan Hound, Cynthia Rose, and Ernst Stavros Grouper. In early press materials for Muppets Tonight, the sketches were said to star Mr. Poodlepants.