Ruin Corp is one of the four original factions from the era of the Great War, i.e. before the Beasts were a threat to humanity. This faction specializes in commerce and research.[1]
In Ruin's illegal labs built for human experimentation, the 104th special Chimera mixed with Beast blood went berserk. Due to its Beast blood a warp marker was created. This marker and the High Rank Beasts that appeared, in turn, caused the Chimeras present to form a type of network, which ultimately lead to the Battle of O'Connelley. During the flashback in the story, Dan Marno is seen smiling at Anne in this lab.[2]